This roundtable explores the critical need for courageous, principled, and radical action to tackle health care’s thorniest challenges, such as increasing polarization, burnout, health disparities, disruption, consolidation, and shifting regulation. Executives in this roundtable are driven to leverage their position, influence, and organization to confront structural impediments facing health care and society more broadly. By sharing personal leadership values and experiences through candid peer-to-peer dialogue, roundtable participants will strengthen their ability to lead their organizations through an increasing pace of change, including tactics for cultivating innovation, diverse perspectives, and a true culture of belonging and respect for our workforce and the people we serve.